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Journal of Leukemia is a peer reviewed medical journal that includes a wide range of fields in Leukemia, Multiple Myeloma, Acute Lymphoblastic Leukemia, Acute Myleoid Leukemia, Chronic Lymphocytic Leukemia, Chronic Myleloid Leukemia, Hairy Cell Leukemia, Pediatric Leukemia, Leukemia drugs, Stem Cell Transplant, Plasma cell Leukemia, Mast cell Leukemia, Lymphoma Cancer, Lymphoma Symptoms, Spleen cancer, Acute Myelomonocytic Leukemia, Aleukemic Leukemia , Lymphosarcoma, Megakaryocytic Leukemia, Feline Leukemia complex, Epidemiologic studies and other Hematologic malignancies and creates a platform for the authors to make their contribution towards the journal and the editorial office promises peer process for the submitted manuscripts to ensure quality.
Leukemia is one of the best open access journals that aims to publish the most complete and reliable source of information on discoveries and current developments in the mode of Original articles, Review articles, Case reports, Short communications, etc. in the field and provides free online access to the researchers worldwide.
This scholarly open access journal is using Editorial Manager System for online manuscript submission, review and the progress of the article. Editorial board members of Journal of Leukemia or outside experts review manuscripts; at least two independent reviewer’s approval followed by the editor is required for the acceptance of any citable manuscript.
Leukemia is a cancer of the blood cells. Leukemia begins in a cell in the bone marrow. The cell undergoes a change and becomes a type of leukemia cell. Once the marrow cell undergoes a leukemic change, the leukemia cells may grow and survive better than normal cells. Over time, the leukemia cells crowd out or suppress the development of normal cells. The rate at which leukemia progresses and how the cells replace the normal blood and marrow cells are different with each type of leukemia.
It is the most common type of blood cancer and affects 10 times as many adults as children. Most people diagnosed with leukemia are over 50 years old.
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Blood, Blood Disorders & Transfusion, Blood & Lymph, Cancer Clinical Trials, Leukemia, Leukemia Research, Leukemia Research Reports, Blood Reviews, Blood Research, Chemotherapy, Cancer Journal, Cancer Biology & Therapy
Acute Lymphoblastic Leukemia
Acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, is a cancer that starts from the early version of white blood cells called lymphocytes in the bone marrow (the soft inner part of the bones, where new blood cells are made). The term “acute” means that the leukemia can progress quickly, and if not treated, would probably be fatal within a few months. Lymphocytic means it develops from early (immature) forms of lymphocytes, a type of white blood cell. Acute leukemia requires aggressive, timely treatment.
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Cancer Diagnosis, Cancer Science & Therapy, Archives in Cancer Research, Leukemia Research, Blood Reviews, Critical Reviews in Oncology/Hematology, Seminars in Oncology, Blood Cancer Journal, Medical Oncology
Acute Myleoid Leukemia
Acute myeloid leukemia (AML) has many other names, including acute myelocytic leukemia, acute myelogenous leukemia, acute granulocytic leukemia, and acute non-lymphocytic leukemia. “Acute” means that this leukemia can progress quickly if not treated, and would probably be fatal in a few months. “Myeloid” refers to the type of cell this leukemia starts from. Most cases of AML develop from cells that would turn into white blood cells (other than lymphocytes), but some cases of AML develop in other types of blood-forming cells.
AML starts in the bone marrow (the soft inner part of certain bones, where new blood cells are made), but in most cases it quickly moves into the blood. It can sometimes spread to other parts of the body including the lymph nodes, liver, spleen, central nervous system (brain and spinal cord), and testicles. It occurs in both adults and children and affects about 18,000 people each year in the U.S.
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Cancer Clinical Trials, Cancer Medicine & Anti Cancer Drugs, Oncology & Cancer Case Reports, Clinical Lymphoma, Myeloma and Leukemia, Hematological Oncology, International Journal of Clinical Oncology, Acta Oncologica, Cancer Control, Seminars in Oncology
Chronic Myleloid Leukemia
Chronic myeloid leukemia (CML), also known as chronic myelogenous leukemia, is a type of cancer that starts in certain blood-forming cells of the bone marrow. In CML, a genetic change takes place in an early (immature) version of myeloid cells - the cells that make red blood cells, platelets, and most types of white blood cells (except lymphocytes). This change forms an abnormal gene called BCR-ABL, which turns the cell into a CML cell. The leukemia cells grow and divide, building up in the bone marrow and spilling over into the blood. In time, the cells can also settle in other parts of the body, including the spleen. CML is a fairly slow growing leukemia, but it can also change into a fast-growing acute leukemia that is hard to treat.
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Cancer Diagnosis, Cancer Science & Therapy, Archives in Cancer Research, Cancer Causes & Control, Critical Reviews in Oncology Hematology, Cancer Science, Journal of Surgical Oncology, Cancer Treatment Reviews, Cancer Chemotherapy and Pharmacology, Journal of Leukemia and Lymphoma
Hairy Cell Leukemia
Hairy cell leukemia is rare. It occurs mostly in people aged 40-60 and is more common in men than in women. HCL usually develops very slowly. HCL affects a type of white blood cell called a B‑lymphocyte. When this cell is examined under a microscope, it looks as if it has hair-like outgrowths (projections) on its surface. This is where HCL gets its name from.
In HCL, the abnormal white blood cells also build up in the spleen and cause it to grow. An enlarged spleen may remove normal blood cells from the bloodstream. This can also reduce the number of red blood cells and normal white blood cells. The causes of HCL are unknown. It is not infectious and cannot be passed on to other people.
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Pediatric Leukemia is also called as Juvenile Leukemia and childhood leukemia. Accounts for less than 1% of childhood leukemias Approx. 25-50 children are diagnosed each year in the US Children are usually diagnosed before 2 years old More common in boys than girls Symptoms can take months to develop Usually no symptoms are seen in the early stages Once diagnosed progressive deterioration occurs.
This Leukemia is the most commonly diagnosed cancer in children, accounting for about 30% of all cases. Approximately 1 in 2,000 children will develop it before the age of 15 years.
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Cancer Clinical Trials, Cancer Medicine & Anti Cancer Drugs, Oncology & Cancer Case Reports, Pediatric Blood and Cancer, Oral Oncology, Molecular Cancer, Cancer Biology & Therapy, Cancer Detection and Prevention, Cancer Journal, Blood Cancer Journal
Plasma Cell Leukemia
Plasma cell leukemia (PCL) is a rare and aggressive plasma cell dyscrasia. Patients with PCL have a very poor prognosis with median survival measured in months. PCL can present de novo or following a prodrome of plasma cell myeloma. Patients with PCL tend to present with aggressive clinical features, such as extramedullary disease, bone marrow failure. The treatment of PCL has primarily been palliative, with only a small minority of patients achieving a durable remission.
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Mast Cell Leukemia
Mast cell leukemia (MCL) is a very rare form of aggressive systemic mastocytosis accounting for < 1% of all mastocytosis. It may appear de novo or secondary to previous mastocytosis and shares more clinicopathologic aspects with systemic mastocytosis than with acute myeloid leukemia. Symptoms of mast cell activation-involvement of the liver, spleen, peritoneum, bones, and marrow-are frequent.The common phenotypic features of pathologic mast cells encountered in most forms of mastocytosis are unreliable in MCL.
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Lymphoma is different from leukemia. Each of these cancers starts in a different type of cell. Lymphoma starts in infection-fighting lymphocytes. Leukemia starts in blood-forming cells inside bone marrow. Lymphoma is also not the same as lymphedema, which is a collection of fluid that forms under the skin when lymph nodes are damaged.
There are two main types of lymphoma:
Non-Hodgkin and Hodgkin lymphoma each affect a different kind of lymphocyte. Every type of lymphoma grows at a different rate and responds differently to treatment.
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The most common symptom of lymphoma is a painless swelling in a lymph node, usually in the armpit, groin or neck. This is caused by the damaged lymphocytes collecting in that node. The swelling may also ache. Fever, Chills, Unexplained weight loss, These symptoms are nonspecific. This means that they could be caused by any number of conditions unrelated to cancer. For instance, they could be signs of the flu or other viral infection, but in those cases, they would not last very long. In lymphoma, the symptoms persist over time and cannot be explained by an infection or another disease.
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Cancer Surgery, Advances in Cancer Prevention, Chemotherapy: Open Access, Blood & Lymph, Leukemia and Lymphoma, Journal of Leukemia and Lymphoma, Oncogene, Seminars in Cancer Biology, Cancer Letters, Cancer Causes and Control, Cancer Immunology and Immunotherapy, Cancer Biology and Therapy, Advances in Cancer Research
Acute Myelomonocytic Leukemia
Acute Myelomonocytic Leukemia one of the more common types of acute myelogenous leukemia, characterized by both malignant monocytes and myeloblasts; it usually affects middle aged to older adults, although it affects people of all ages. AML sometimes is caused by chemotherapy or radiation therapy given to treat another cancer.
In AML, immature leukemia cells rapidly accumulate in the bone marrow, destroying and replacing cells that produce normal blood cells. The leukemia cells are released into the bloodstream and are transported to other organs, where they continue to grow and divide. They can form small masses (chloromas) in or just under the skin or gums or in the eyes. There are several subtypes of AML, which are identified based on characteristics of the leukemia cells.
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Leukemia is a serious disease, a cancer of blood or bone marrow. It is a cancer of white blood cells (WBCs). Abnormal production of leukocytes or white blood cells in the bone marrow leads to leukemia, resulting in several health complications. Aleukemic Leukemia is a leukemia in which the leukocyte count is normal or below normal.
In aleukemic leukemia, increased number of white blood cells is not detected in a blood test. It is a rare type of leukemia. This type of leukemia can also be lymphocytic, monocytic, or myelogenous. It can be seen in patients diagnosed with acute/chronic lymphocytic/meylogenous leukemia and also in prolymphocytic leukemia, and myelodysplastic syndrome.
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Acute Megakaryocytic Leukemia
Acute megakaryocytic leukemia (AMeL) is a rare form of acute myeloid leukemia (AML). Even if it is a well-known entity, it could be frequently misdiagnosed as acute myelosclerosis. The disease is rare and, due to difficulty in diagnosis, its exact incidence is not known. Reasonably, it may account for approximately 1-2% of all de novo acute myeloid leukemias (AML) in the adult population, but the incidence in the pediatric age group is higher, partly due to an association with Down syndrome. The incidence of this form of AML shows a high variability according to the different reports, that it ranges from 8 to 15% of all acute leukemias. Clinical experience with this rare leukemia remains limited.
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Feline Leukemia Complex
Feline leukemia is a cancerous disease caused by feline leukemia virus (FeLV). Feline leukemia is a disease that only affects cats -- it cannot be transmitted to people, dogs, or other animals. FeLV is passed from one cat to another through saliva, blood, and to some extent, urine and feces. The virus does not live long outside the cat’s body -- probably just a few hours. FeLV is a type of virus called a retrovirus.
Only about 3% of cats in single-cat households have the virus, but for cats that spend time outdoors, the rate is much higher. Still, the prevalence of FeLV has decreased over the last 25 years because of vaccines and reliable tests.
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OMICS International through its Open Access Initiative is committed to make genuine and reliable contributions to the scientific community. OMICS International hosts over 700 leading-edge peer reviewed Open Access Journals and organizes over 1000 International Conferences annually all over the world. OMICS International journals have over 10 million readers and the fame and success of the same can be attributed to the strong editorial board which contains over 50000 eminent personalities that ensure a rapid, quality and quick review process. OMICS International signed an agreement with more than 1000 International Societies to make healthcare information Open Access. OMICS International Conferences make the perfect platform for global networking as it brings together renowned speakers and scientists across the globe to a most exciting and memorable scientific event filled with much enlightening interactive sessions, world class exhibitions and poster presentations.
Journal of Leukemia is supporting the 5th World Conference on Cancer Therapy during september 28-30, 2015 Atlanta, USA with the theme of Exploring the Possibilities towards cancer treatment.
Survivors of Blood or Marrow Transplantation Are Likely to Experience Cognitive Impairment
Feb. 20, 2018 Allogeneic blood or marrow transplantation recipients are at a significantly higher risk of cognitive impairment in the years post-transplantation, according to a new study. The research helps add a ... read more
Enhancing Chemotherapy's Efficiency Against Leukemia
Dec. 12, 2017 Researchers have found a mechanism through which certain types of leukemia resist chemotherapy, revealing novel molecular targets to improve this therapy's ... read more
AML Study Reports High Response Rates With Combination Targeted Therapy
Dec. 11, 2017 Initial findings from a multi-national open-label phase Ib study of inhibitory drug therapy for relapsed or refractory acute myeloid leukemia (AML) have demonstrated a complete response in up to 50 ... read more
Rapid Responses, Few Adverse Effects in Targeted Agent in Phase 1 Trial in Rare Blood Disorder
Dec. 10, 2017 A new study shows one of multiple ways in which novel targeted cancer therapies are now being deployed to improve outcomes and quality of life for patients with rare, advanced, or difficult-to-treat ... read more
Dec. 5, 2017 Using a database of multiple myeloma patient samples and information, researchers found that high ADAR1 levels correlate with reduced survival rates. They also determined that blocking the enzyme ... read more
Communication Between Lung Tumors, Bones Contributes to Tumor Progression
Nov. 30, 2017 Investigators have identified a way in which a type of lung cancer co-opts a portion of the immune system to increase tumor ... read more
Nov. 27, 2017 A new study has found an unexpected new drug target for acute myeloid leukemia that could open new avenues to develop effective treatments against this potentially lethal disease. Researchers show ... read more
High Levels of Natural Immune Suppressor Correlate With Poor Survival in the Most Common Leukemia
Nov. 27, 2017 Patients diagnosed with the most common form of leukemia who also have high levels of an enzyme known to suppress the immune system are most likely to die early, researchers ... read more
HLF-Gene Controls Generation of Our Long-Term Immune System
Nov. 22, 2017 When the HLF (hepatic leukemia factor) gene -- which is expressed in immature blood cells -- does not shut down on time, we are unable to develop a functional long-term immune system, investigators ... read more
New Cell Therapy for Relapsed Leukemia Patients, Suggested by Clinical Trial
Nov. 20, 2017 A significant proportion of children and young adults with treatment-resistant B-cell leukemia who participated in a small study achieved remission with the help of a new form of gene therapy, ... read more
Misregulated Protein Breakdown Promotes Leukemias and Brain Cancer
Nov. 8, 2017 An enzyme that is responsible for the breakdown of specific amino acids in food plays a key role in the development of leukemias and brain cancer, scientists have now reported. The researchers have ... read more
Fat Cells May Inactivate Chemotherapeutic Drug
Nov. 8, 2017 Adipocytes, or fat cells, can absorb and metabolize the chemotherapeutic agent daunorubicin, reducing the effectiveness of the drug and potentially contributing to poorer treatment ... read more
Role of a DNA Repair Mechanism
Oct. 31, 2017 An important step forward in understanding more exactly what the mechanisms are that allow, if not correctly repaired, certain DNA breaks to be exchanged with others, so generating chromosomal ... read more
Important Mechanism of Epigenetic Gene Regulation Identified
Oct. 30, 2017 How can defective gene activity, which can ultimately lead to cancer, be avoided? Researchers now identified a mechanism how cells pass on the regulation of genetic information through epigenetic ... read more
Oct. 26, 2017 In many metastasized types of cancer, disseminated tumors grow back despite successful chemotherapy. As a research team has now discovered, this is because of isolated cancer cells that survive the ... read more
Oct. 25, 2017 Researchers have developed a novel way to genetically engineer T cells that may be effective for treating and preventing leukemia relapse. The findings provide the basis for launching a ... read more
Oct. 25, 2017 A new class of drugs for blood cancers such as leukemia and multiple myeloma is showing promise. But it is hobbled by a problem that also plagues other cancer drugs: targeted cells can develop ... read more
Oct. 23, 2017 In B cell tumors, mutated overactive versions of the Notch protein directly drive the expression of the Myc gene and many other genes that participate in B cell signaling pathways, researchers have ... read more
Bolstering Fat Cells Offers Potential New Leukemia Treatment
Oct. 16, 2017 Killing cancer cells indirectly by powering up fat cells in the bone marrow could help acute myeloid leukemia patients, says a new study. Researchers found that boosting adipocytes, or fat cells, ... read more
Oct. 9, 2017 Scientists have discovered the first compound that directly makes cancer cells commit suicide while sparing healthy cells. The new treatment approach, described in today’s issue of Cancer Cell, was ... read more
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